Thanks to all for the guidance. I disabled any BIOS level COM ports just in case of a system conflict between physical and virtual COM Ports. Both x32 and x64 versions of the Software give the same error.
On a good note, I spun up a new WIN10 Virtual Machine and did a pass through for the USB and the software worked. Not the optimal solution, but it worked.
Thanks to all for the suggestions. I will continue to troubleshoot the main system, but at least I can now start programming.
Thanks!!
James