FRS radio's are short range and low power using simplex only. Most of the time I just ignore them. If they become a problem, I just put a privacy code on the channel's they use so I don't have to hear them. And of course there is the "little girl" transmission ploy.
I never respond to anyone without a call sign unless it is an emergency request. I then call 911 and tell them what I heard. That has happened twice and once it was a true emergency. I am glad we share FRS with GMRS and am willing to put up with some minor inconvenience.