All the channels are very close together so it it highly unlikely that there will be much difference from channel to channel. Find a quiet channel and have at it. Just understand that your radios transmit at 0.5 watts for the FRS only frequencies and about 1.5 watts for the GMRS and GMRS/FRS frequencies. That means that you should be able to reach out further on any of the GMRS or GMRS/FRS channels. Just remember that terrain and buildings can be obstacles to radio signals. Elevation matters, too. Woodlands can impair them, but you'll have to experiment in your particular settings to be sure.