I'm of the school of professional installers (MECP) who never fuse the negative side of electronics in a modern negative-ground vehicle, but then I also NEVER hook anything directly to the battery of any vehicle made after 1995 or so. That really old-school thought from the 60s and 70s needs to be re-educated. If you think you absolutely MUST hook the radio "straight to the battery", then I guess you should fuse both leads. If you want to do it right, the negative lead should be hooked directly to the body electronics common, or "Star" ground point of the vehicle, (the primary ground for body accessories, isolated from starter) and the positive should be hooked to the vehicle manufacturer's designated accessory power takeoff point with the proper sized fuse as close the the power takeoff point as possible. (Power takeoff point is usually located within 2 feet of the battery, fed with a LARGE red wire, and is normally a plastic-capped block with a large bolt that has everything else hooked to it.) If you install the accessories like the car manufacturer intends you to do, and you never hook anything straight to the battery, then you won't need to worry about the starter back-feeding through your antenna and blowing up your radio. Hooking a radio straight to the battery in any modern car is foolish, and can cause noise pickup from the car's other electronics.