Getting help in those situations relying on low power FRS/GMRS units will be spotty at best. While more people are installing and using these radios, they are not widespread. Portable, hand-held radios have a radiated signal of 5 watts power, just like the vast majority of radios used by others. Mobile or in-car units can have up to 50 watts of power on some frequencies. The primary issue is having another station in range which is why it would be hit-or-miss. The other radio services available to most people, CB and amateur have many more users and a greater chance of being able to reach another party. CB has 40 channels with a more structured use in that there are some channels used primarily for travel. The problem with a hand-held walkie-talkie is the antenna length needed for its lower frequencies. FRS/GMRS operates at a much higher frequency band so the hand-held antennas range from 6 inches to about 19 inches. This is off-set by the fact two stations have to be virtually in a straight line from each other or in line-of-sight. GMRS radios can use repeaters which will allow a signal to be retransmitted from another location to cover more distance. Repeaters are not real common, but there are a lot of them in-service.
Amateur, or ham radio is another option. The portable, hand-held units have roughly the same power as the others but have many more frequencies or channels on which to operate and a very robust repeater infrastructure. Both GMRS and amateur require FCC granted licenses to operate. GMRS doesn't require any more than the license and equipment while amateur requires some knowledge of both radio and the regulations proven through a 35 question test. Amateur equipment is generally more expensive than GMRS, but that's off-set by its flexibility and greater infrastructure.
In use, ham and CB share in the fact they both are used for talking between stations without the language found on CB. FRS, limited to very low power is often used by families and children with some business thrown in. You won't find much in the way of general conversational use on GMRS due to the low overall number of users. My recommendation is to get licensed for both amateur (Technician) and GMRS. Use both on the road but amateur on the trail.