Absolutely. Eight of the main GMRS frequencies (462.550, .575, .600, .625, .650, .675, .700, .725) are all allowed 50watts when used simplex or with a repeater. These are often called channels 15-22. Their 467MHZ companions (i.e. the other eight main GMRS frequencies) are not permitted for simplex use. If you were to illegally use the 467MHz Main frequencies for simplex, you are likely to negatively affect local repeaters that use them as their input frequencies, so do not ever do that. You are on the right track. Always use as little power as necessary to get the job done. Finally, you are also on the right track too to pick a simplex frequency that is not being used so as to avoid interference with others. That is always a wise decision. Hope this helps. Michael WRHS965 KE8PLM